Endocrine Abstracts

Hyperinsulinism has been shown to trigger sympathetic activity experimentally, however the clinical and epidemiologic data on the association of heart rate with hyperinsulinism and insulin resistance. This study was investigated the relationship between insulin resistance and exercise test parameters in unselected consecutive middle aged asymptomatic patients with type II diabetes.Ninety asymptomatic type II diabetics between the ages 36 and 60 without a...

Accelerated coronary and peripheral vascular atherosclerosis is one of the most common and chronic complications of diabetes mellitus. A relatively recently analysed aspect of coronary artery disease in this condition is its silent nature. We studied silent myocardial ischaemia (SMI) in unselected consecutive middle aged asymptomatic patients with type II diabetes by treadmill exercise test.Ninety four asymptomatic type II diabetics between the ages 36 a...

Aim: Mitotane (o,p′-DDD) has been used to treat adrenocortical carcinoma (ACC) for several decades. Mitotane is often given in adjuvant setting after surgical resection of ACC and treatment usually lasts 2–3 years to reduce ACC recurrence. The use of mitotane is associated with multiple adverse effects. We herein report a case of marked hypercholesterolemia in a man receiving mitotane as adjuvant chemotherapy for ACC.Case: A 64-year-old man wa...

Introduction: Langerhans cell histiocytosis (LHH) is an idiopathic, clonal, pleomorphic, neoplastic disorder characterized by the presence of atypical histiocytic cells which are locally or commonly seen in bone, lung, hypothalamus, liver, lymph nodes, mucocutaneous tissues with damaging them.Case: 58 year-old male patient applied to our clinic due to fatigue. On his physical examination, lymphadenopathy and hepatosplenomegaly were absent. In his history...

Aim: Diabetic foot is a devastating complication of diabetes mellitus. Many factors such as neuropathy, vascular injury and infection contribute in the development of diabetic foot. Programmed cell death is a pathway that causes a tendency for the development of atherosclerosis. Whereas Fas/Fas ligand pathway induces apoptosis, osteoprotegerin (OPG) causes calcification in vascular area and also effects apoptotic pathway. In the present study, we aimed to investigate the role ...

Pheochromocytomas are tumors capable of producing catecholamines and a variety of biologically active resulting in unusual clinical manifestations. We report the case of 18-year-old female with pheochromocytoma exhibiting fever of unknown origin. She had experienced continuous fever (ranging between 37.1–41  °C) and chills for previous several weeks. Antipyretics had been ineffective in lowering the body temperature and she was referred to our hospital when an a...

Objective: Low skeletal muscle mass is an emerging risk factor for metabolic disorders. In this study, we aimed to evaluate the relationships between fat mass, muscle mass, muscle fat mass ratio, total fat mass, and abdominal fat mass ratio by comparing the body compositions in obese women with and without metabolic syndrome.Methods: Totally 89 obese women (mean±S.D., age 42.1±12 years, BMI 36.5±4.2%) with newly diagnosed me...

Aim: Acromegaly is associated with accelerated atherosclerosis and cardiovascular disease. Nitric oxide (NO) is enzimatically formed from L-arginine by endothelial nitric oxide synthase (eNOS). Several studies have shown that reduction in NO synthesis causes endothelial dysfunction and impaired endothelium-dependent vasodilation. Asymmetric dimethylarginine (ADMA), the endogenous inhibitor of NOS, accumulation plays a prominent role in the pathogenesis and in pr...

Objective: Thyroid diseases are among the most common endocrine disease and with a prevalence of 1.2%. Thyroid hormones have several effects on cardiovascular system. Many studies showed the association between hyperthyroidism and acute ischemic heart disease with conflicting results. Epicardial adipose tissue (EAT) thickness is a marker of atherosclerosis and independent predictor of coronary artery disease. In this study, we aimed to evaluate the EAT thickness in patients wi...

Objective: The relationship between metabolic syndrome (MS) and hypogonadism has always been investigated in study groups confounded with aging, obesity or chronic metabolic disorders. So far there has been no data about the presence of MS in young hypogonadal patients. Also there is controversial data about the metabolic effects of testosteron replacement therapy. We investigated the frequency of MS in treatment naïve, young men with congenital hypogonadal hypogonadism (...